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New way to reprogram lymph node function to fight multiple sclerosis - Science Daily

"Our lab is combining immunology and nanotechnology to reprogram how the immune system responds to self-cells in the brain that are mistakenly attacked during MS," said BIOE Assistant Professor Christopher Jewell, corresponding author on the new... "The finding, conducted in cells and pre-clinical animal models of MS, could lead to new approaches for reversing paralysis in MS, or better therapies for other autoimmune diseases. Collaborator Dr. Jonathan Bromberg from the University of Maryland School of Medicine said, "The studies show it is possible to treat and cure inflammatory disease with a single dose of therapeutics loaded in biodegradable polymers targeted... In MS, the immune system incorrectly recognizes myelin that insulates and protects nerves fibers in the brain. Immune cells enter the brain and attack, leading to slow loss of motor function and other complications. Current therapies for MS work by decreasing the activity of the immune system. "The goal of our work -- and that of others in the field -- is to expand cells that are both myelin-specific and regulatory in nature," said Lisa Tostanoski, first author on the paper. "The hope is that these cells can directly suppress inflammation without targeting healthy immune function. Jewell's team is working to reprogram the function of lymph nodes: instead of generating inflammatory cells that attack myelin, the lymph nodes are "instructed" to promote regulatory immune cells that control the attack against myelin. To carry out the "reprogramming," degradable polymer particles that incorporate regulatory signals are delivered to lymph nodes using a unique intra-lymph node injection technique. Once in the lymph nodes, these particles slowly release immune signals to promote regulatory immune cells that mature and migrate to the central nervous system to suppress the attack against myelin. Importantly, these effects were found to be myelin-specific, and correlated with local changes in the function and types of cells in lymph nodes and the central nervous system. "Moving forward, our team is working to show the therapeutic effects result from repair and remyelination in the brain," Jewell said. Source: www.sciencedaily.com

Latest News

  • New way to reprogram lymph node function to fight multiple sclerosis

    09/15/16 ,via Science Daily

    Lisa H. Tostanoski, Yu-Chieh Chiu, Joshua M. Gammon, Thomas Simon, James I. Andorko, Jonathan S. Bromberg, Christopher M. Jewell. Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific.

  • RL Maynard

    08/22/16 ,via Murfreesboro Post

    and siblings, James, Bonell, Joseph, Ed, Dean, Francis, Reba, Flossie, and Johnny. Survivors include his wife of 60 years, Dovie May Warrick Maynard; children, Kathy Smith of Shelbyville, Peggy Gammon-Nelson, Bobby Maynard and wife Tina, and Penny 

Twitter

James Gammon -- (4/20/1940-7/16/2010). American Actor. He portrayed Nick Bridges on TV Series "Nash https://t.co/MqOV1Ln6vi 09/19/16, @srhgrdnr
RT @MarinersMuseum: Entrancing photo of the James River by the Lions Bridge! Captured by Jerry Gammon. https://t.co/dvAANFbGxO 09/16/16, @Gonegonz
RT @MarinersMuseum: Entrancing photo of the James River by the Lions Bridge! Captured by Jerry Gammon. https://t.co/dvAANFbGxO 09/16/16, @rkmeeks7

Recipes

  • James Beard's Chicken Kiev

    chicken, butter, chives, eggs, flour, garlic, parsley, black pepper, rosemary, salt, vegetable oil, water

Books

  • People from Douglas County, Illinois

    General Books. 2010. ISBN: 1155240111,9781155240114. 58 pages.

Bing news feed

  • Windmill Country: Fall Roundup kicks off, rain continues

    09/13/16 ,via Abilene Reporter-News

    However, his grandson, James Uhl, who lives at the ranch ... said state climatologist John Nielsen-Gammon in College Station. "Two corners of the state with severe drought at the beginning of August, the South Plains in the Lubbock area and northeast ...

  • New way to reprogram lymph node function to fight multiple sclerosis

    09/16/16 ,via Science Daily

    The additional authors on the work are BIOE researchers Dr. Yu-Chieh Chiu, Joshua Gammon, and James Andorko, and Dr. Thomas Simon at the University of Maryland School of Medicine. University of Maryland. (2016, September 15). New way to reprogram lymph ...

  • Dan River Region real estate transfers

    09/08/16 ,via GoDanRiver

    James O. Weakley III to Steven W ... Miller and Jennifer M. Miller to George R. Gammon, 50 feet, lot eight, section M, 122 Schoolfield Drive, $7,250. » St. John One Accord Holiness Church to Katie E. Logan and John J. Cobbs, 50 feet, lot C, 139 and ...

Directory

James Gammon - IMDb

James Gammon, Actor: The Iron Giant. Rugged-looking James Gammon first broke into the entertainment industry not as an actor but as a TV cameraman. From there, his ...

James Gammon - Wikipedia, the free encyclopedia

James Gammon; Born (1940-04-20) April 20, 1940 Newman, Illinois, U.S. Died: July 16, 2010 (2010-07-16) (aged 70) Costa Mesa, California, U.S. Cause of death

James Gammon - Biography - IMDb

Rugged-looking James Gammon first broke into the entertainment industry not as an actor but as a TV cameraman. From there, his weatherbeaten features...

James Gammon – Wikipedia

James Gammon (* 20. April 1940 in Newman, Illinois; † 16. Juli 2010 in Costa Mesa, Kalifornien) war ein US-amerikanischer Schauspieler. Leben. Er wuchs in Orlando ...

... James Gammon excelled most typically as weathered, rustic types

... James Gammon excelled most typically as weathered, rustic types

James Gammon (1940-2010)

James Gammon (1940-2010)

James Gammon

James Gammon
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